PUBLICATIONS

INVITED ARTICLES (independent author)

• Ph.D. Skills, Revisited: Companies are Beginning to Realize the Added Value Ph.D. Holders can Provide at the Front Line of Business. Biotechnology Focus. March/April 1999
• The Troubled Helix - A Look at the HR Issue in the Biotech/Pharma Industries. Biotechnology Lab Report. In press (June 1999)

SUBMITTED PATENTS

• Protein Which Interacts With The Huntington's Disease Gene Product, cDNA Coding Therefor, And Antibodies Thereto (US patent application # 60/006,882) - 1996 Co-inventors: Michael A. Kalchman and Michael R. Hayden
• Apoptosis Modulators That Interact With The Huntington's Disease Gene Co-inventors: UBC - Michael A. Kalchman, Abigail Hackam, Vic Chopra, Michael R. Hayden; Merck-Frosst - Deita Rasper, John Vallaincourt, Donald Nicholson - (CPT as per # 60/006,882)

FIRST AUTHOR MANUSCRIPTS (PEER REVIEWED)

• HIP1, a Human Homolog of S. cerevisiae Sla2p, Interacts with Membrane-Associated Huntingtin in the Brain, Nature Genetics (1997). 16: 44-53.
• Huntingtin interacts with a ubiquitin conjugating enzyme which is highly expressed in brain. Journal of Biological Chemistry (1996). 271: 19385-19394.

OTHER MANUSCRIPTS (PEER REVIEWED)

• The influence of huntingtin protein size on nuclear localization and cellular toxicity. Journal of Cell Biology. (1998). 141: 1097-1105.
• Absence of Disease Phenotype and Intergenerational Stability of the CAG Repeat in Transgenic Mice Containing the Huntington Disease Gene. Human Molecular Genetics (1996). 5: 177-185.
• Proteolytic cleavage of Huntingtin by apopain, a key proapoptotic cysteine protease. Nature Genetics (1996). 13: 442-449.
• Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms. Genomics (1995). 25: 707-715.
• Identification of an Alu retrotransposition event in close proximity to a strong candidate gene for Huntington's disease. Nature (1993). 362: 370-373.
• A transcription map of the proposed region for the Huntington disease gene. Human Molecular Genetics (1993). 2: 901-907.
• The relationship between trinucleotide repeat length (CAG) and clinical features of Huntington disease. Nature Genetics (1993). 4: 398-403.
• Differential 3' polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression. Human Molecular Genetics (1993). 2: 1541-1545.

ABSTRACTS (PEER REVIEWED)

• University of British Columbia Medical Genetics Retreat. Vancouver, BC, August 1997.
• Yeast Genetics and Human Disease Conference. Baltimore, Maryland, November 1996.
• American Society of Human Genetics Annual Mtg. San Francisco, California, October 1996.